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Steelers Open as 6.5-Point Underdogs at Buffalo Week 1

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The Pittsburgh Steelers will kickoff the 2021 season visiting the Buffalo Bills, and have opened as 6.5-point underdogs, courtesy of DraftKings Sportsbook.

Buffalo-Pittsburgh is tied with Tampa Bay-Dallas for the second-largest spread opening weekend. The Detroit Lions are the biggest underdogs at +7.5 against the San Francisco 49ers.

While the Steelers lead the all-time at 16-11-0, they have dropped their last two meetings with the Bills by an average of nine points.

Buffalo quarterback Josh Allen passed for 238 yards and two touchdowns with an interception in the win. Wide receiver Stefon Diggs was virtually unguardable for the Bills catching ten passes for 130 yards and a score.

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Steelers quarterback Ben Roethlisberger passed for 187 yards and two scores, but threw a pair of costly interceptions, including one that was returned 51 yards for a touchdown.

Pittsburgh also mustered just 47 yards on the ground.

Both teams reached the postseason last year, but the Bills went all the way to the AFC Championship game, ultimately falling to the Kansas City Chiefs 38-24.

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