The Pittsburgh Steelers will face the Cincinnati Bengals to open the 2022 regular season this Sunday, Sept. 11 at Paycor Stadium on the banks of the Ohio River in Cincinnati.
The Steelers will largely line up against the Bengals much as have throughout the preseason, and that was made official with the release of the team’s official depth chart for Week 1.
| QB | 10 Mitch Trubisky | 2 Mason Rudolph | 8 Kenny Pickett |
| RB | 22 Najee Harris | 30 Jaylen Warren | 24 Benny Snell Jr. |
| FB | 44 Derek Watt | ||
| WR | 18 Diontae Johnson | 89 Gunner Olszewski | |
| WR | 14 George Pickens | 13 Miles Boykin | |
| WR | 11 Chase Claypool | 82 Steven Sims | 19 Calvin Austin III (IR) |
| TE | 88 Pat Freiermuth | 81 Zach Gentry | 83 Connor Heyward |
| LT | 65 Dan Moore Jr. | 72 Trent Scott | |
| LG | 69 Kevin Dotson | 53 Kendrick Green | |
| C | 61 Mason Cole | 60 J.C. Hassenauer | |
| RG | 78 James Daniels | ||
| RT | 76 Chukwuma Okorafor | 77 Jesse Davis | |
| DL | 97 Cam Heyward |
92 Isaiah Loudermilk 98 DeMarvin Leal |
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| NT | 94 Tyson Alualu | 57 Montravius Adams Sr. |
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| DL | 65 Larry Ogunjobi | 95 Chris Wormley | |
| OLB | 56 Alex Highsmith |
48 Jamir Jones | |
| ILB | 51 Myles Jack | 93 Mark Robinson | 27 Marcus Allen |
| ILB | 55 Devin Bush Jr. | 41 Robert Spillane | |
| OLB | 90 T.J. Watt | 50 Malik Reed | |
| CB | 20 Cameron Sutton | 29 Levi Wallace | |
| CB | 25 Ahkello Witherspoon | 42 James Pierre | |
| NB | 35 Arthur Maulet | ||
| FS | 39 Minkah Fitzpatrick | 21 Tre Norwood | 24 Damontae Kazee (IR) |
| SS | 34 Terrell Edmunds | 28 Miles Killebrew | |
| K | 9 Chris Boswell | ||
| P | 6 Pressley Harvin III | ||
| LS | 46 Christian Kuntz | ||
| KR | 89 Gunner Olszewski | 82 Steven Sims |